解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Colorectal cancer (CRC) is one of the most common cancers and causes of cancer-related death. There are several first-line chemotherapeutic drugs used to treat CRC. Oxaliplatin (OXA) is an alkylating cytotoxic agent that is usually combined with other chemotherapeutic drugs to treat stage II and stage III CRC. However...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22544
更新日期:2018-05-01 00:00:00
abstract::Although marine and coastal environments which are contaminated with xenobiotic organic compounds often become hypoxic during the summer, the interactive effects of hypoxia and xenobiotic exposure on marine species such as teleost fishes remain poorly understood. The expression and activity of monooxygenase enzyme cyt...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22527
更新日期:2018-04-01 00:00:00
abstract::Throughout life, the human eye is continuously exposed to sunlight and artificial lighting. Ambient light exposure can lead to visual impairment and transient or permanent blindness. To mimic benign light stress conditions, Mus musculus eyes were exposed to low-energy UVB radiation, ensuring no severe morphological ch...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22494
更新日期:2018-01-01 00:00:00
abstract::Oral submucous fibrosis (OSF) has been indicated as one of the oral potentially malignant disorders. Epidemiological studies have attributed this pathological fibrosis to the habit of areca nuts chewing, which causes chronic inflammation and persistent activation of myofibroblasts in the oral cavity. Hence, it is cruc...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22489
更新日期:2018-01-01 00:00:00
abstract::Fluoride exposure is widespread, with drinking water commonly containing natural and artificially added sources of the ion. Ingested fluoride undergoes absorption across the gastric and intestinal epithelia. Previous studies have reported adverse gastrointestinal effects with high levels of fluoride exposure. Here, we...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22495
更新日期:2018-01-01 00:00:00
abstract::In the present study, responses of the Chinese brown frog (Rana chensinensis) to exposure to di-2-ethylhexyl phthalate (DEHP), a common plasticizer, during the larval period were characterized. The effects of DEHP on metamorphosis rate, thyroid hormone, thyroid histology and the expression of genes involved in the ste...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22504
更新日期:2018-01-01 00:00:00
abstract::Dibutyltin (DBT) is the degradation products of TBT, which is generally considered higher toxicity than TBT in the immune system. In order to learn more about the mechanisms of immune-toxic of DBT, we exposed zebrafish (Danio rerio) to 0, 1, 10 and 100 ng/L DBT for 8 weeks. At the end of the experiment, we determined ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22502
更新日期:2018-01-01 00:00:00
abstract::The environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is known to affect bone metabolism. We evaluated the protective effects of the triterpene glycoside actein from the herb black cohosh against TCDD-induced toxicity in MC3T3-E1 osteoblastic cells. We found that TCDD significantly reduced cell viabil...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22459
更新日期:2017-12-01 00:00:00
abstract::Nickel oxide nanoparticles (nano NiO) could induce hepatocyte apoptosis, while its potential mechanisms are unclear. This study aimed to explore the role of endoplasmic reticulum (ER) stress pathways in hepatocyte apoptosis induced by nano NiO. Male Wistar rats were administrated with nano NiO (0.015, 0.06, and 0.24 m...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22492
更新日期:2017-12-01 00:00:00
abstract::Melanoma is the leading cause of death from skin disease due to its propensity for metastasis. Studies have shown that integrin-mediated focal adhesion kinase (FAK) signal pathway is implicated in cell proliferation, survival and metastasis of tumor cells. Our previous results indicated that diallyl trisulfide (DATS) ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22445
更新日期:2017-11-01 00:00:00
abstract::Nanoparticulate titanium dioxide (nano-TiO2 ) has been widely used in industry, medicine and daily life. However, assessment of nano-TiO2 toxicity on health is an important occupational safety issue. Numerous studies have demonstrated that nano-TiO2 can induced sustained pulmonary inflammation, but whether chronic exp...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22493
更新日期:2017-09-25 00:00:00
abstract::Casticin, a polymethoxyflavone, is one of the major active components obtained from Fructus viticis, which have been shown to have anticancer activities including induce cell apoptosis in human cancer cells. The aim of this study was to investigate the molecular mechanisms by which casticin inhibits cell migration and...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22417
更新日期:2017-09-01 00:00:00
abstract::Chlorpyrifos (CPF) is one of the most widely used organophosphorus, which has spurred renewed interest. This study was conducted to investigate the protective effect of ziziphora tenuior extract against CPF-induced liver and lung toxicity. This study conducted 8-week rat sub-chronic toxicity study and then the effect ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22432
更新日期:2017-09-01 00:00:00
abstract::Arsenite has been shown to induce a variety of oxidative damage in mammalian cells. However, the mechanisms underlying cellular responses to its adverse effects remain unknown. We previously showed that the level of Nrf2, a nuclear transcription factor significantly increased in arsenite-treated human bronchial epithe...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22374
更新日期:2017-08-01 00:00:00
abstract::di-N-butylphthalate (DBP) is a ubiquitous environmental pollutant used for plastic coating and in the cosmetics industry. It has toxic effects on body health, especially the male reproductive system. Here, we investigated the effects of DBP on the male reproductive system of pubertal mice and explored the protective r...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22413
更新日期:2017-07-01 00:00:00
abstract::Renal cell carcinoma (RCC) is the most common type of kidney cancer in adults and the major cause of mortality in urological cancer. Most patients with RCC are asymptomatic until the disease is advanced and unresectable. In this situation, systemic therapy with immunotherapy or molecularly targeted therapy agents play...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22411
更新日期:2017-07-01 00:00:00
abstract::Malathion is one of the most commonly used insecticides. Recent findings have demonstrated that it induces oxidative stress in somatic cells, but there are not enough studies that have demonstrated this effect in germ cells. Malathion impairs porcine oocyte viability and maturation, but studies have not shown how oxid...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22384
更新日期:2017-06-01 00:00:00
abstract::Oral cancer is one of the cancer-related diseases in human populations and its incidence rates are rising worldwide. Fisetin, a flavonoid from natural products, has been shown to exhibit anticancer activities in many human cancer cell lines but the molecular mechanism of fisetin-induced apoptosis in human oral cancer ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22396
更新日期:2017-06-01 00:00:00
abstract::Tris (1,3-dichloro-2-propyl) phosphate (TDCIPP) is one of the widely used organophosphorus flame retardants (OPFRs), which are regarded as suitable substitutes for brominated flame retardants (BFRs). Previously, we have validated the toxicity of TDCIPP in PC12 cells owing to the induced alterations in GAP43, NF-H, CaM...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22401
更新日期:2017-06-01 00:00:00
abstract::Aluminum methylcyclohexylphosphinate (AMHP), calcium methylcyclohexylphosphinate (CMHP), aluminum diethylphosphinate (ADEP), and aluminum methylethylphosphinate (AMEP) are organic dialkyl phosphinates (DPs) and emerging phosphorus-based flame retardants. The broad-spectrum DPs flame retardants occupy high-end industri...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22383
更新日期:2017-05-01 00:00:00
abstract::This work investigated the effects of mercury chloride (HgCl2 ) acute exposure on virgin, pregnant and lactating rats by determination of renal and hepatic morphological and ultrastructural parameters and the expression of oxidative stress and stress tolerance markers, due to kidney and liver are the organs that more ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22370
更新日期:2017-05-01 00:00:00
abstract::Chronic inhalation bioassays in rodents are used to assess pulmonary carcinogenicity for purposes of hazard identification and potentially for risk characterization. Numerous studies have been confirmed that exposure to titanium dioxide nanoparticles (TiO2 NPs) may result in chronic pulmonary inflammation in both mice...
journal_title:Environmental toxicology
pub_type: 杂志文章,收录出版
doi:10.1002/tox.22393
更新日期:2017-05-01 00:00:00
abstract::Several estuaries along the Pacific Ocean coast of North America were identified recently as having elevated 4-nonylphenol (4-NP) in sediments and biota, raising concerns about reproductive impacts for wildlife given 4-NP's established estrogenic activity as an endocrine-disrupting compound. Here we characterize 4-NP ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22371
更新日期:2017-05-01 00:00:00
abstract::Glyphosate is the active ingredient of several herbicide formulations. Different reports suggest that glyphosate-based herbicides (GBHs) may act as endocrine disruptors. We evaluated the potential estrogenic effects of a GBH formulation using the uterotrophic assay. Adult ovariectomized rats were sc injected for 3 con...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22316
更新日期:2017-04-01 00:00:00
abstract::Nonsmall cell lung cancer (NSCLC) is the most common type of lung cancer with a high mortality rate and still remains a therapeutic challenge. A strategy for targeting NSCLC is to identify agents that are effective against NSCLC cells while sparing normal cells. Dihydromyricetin (DHM) is the major flavonoid component ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22336
更新日期:2017-04-01 00:00:00
abstract::Human exposure to bisphenol A (BPA) could favor obesity and related metabolic disorders such as hepatic steatosis. Investigations in rodents have shown that these deleterious effects are observed not only when BPA is administered during the adult life but also with different protocols of perinatal exposure. Whether pe...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22301
更新日期:2017-03-01 00:00:00
abstract::Andrographolide, the main bioactive component of the medicinal plant Andrographis paniculata, has been shown to possess potent anti-inflammatory activity. Endothelin 1 (ET-1), a potent vasoconstrictor peptide produced by vascular endothelial cells, displays proinflammatory property. Hypoxia-inducible factor 1α (HIF-1α...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22293
更新日期:2017-03-01 00:00:00
abstract::Ionic liquids (ILs) are widely used as reaction media in various commercial applications. Many reports have indicated that most ILs are poorly decomposed by microorganisms and are toxic to aquatic organisms. In this study, differential gene expression profiling was conducted using a suppression subtraction hybridizati...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22244
更新日期:2017-02-01 00:00:00
abstract::The aim of this study was to determine whether repeated exposure to iron oxide nanoparticles (Fe2 O3 -NPs) could be toxic to mice testis. Fe2 O3 -NPs (25 and 50 mg/kg) were intraperitoneally administered into mice once a week for 4 weeks. Our study showed that Fe2 O3 -NPs have the ability to cross the blood-testis bar...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22262
更新日期:2017-02-01 00:00:00
abstract::This study assessed the potential hepatoprotective effect of telmisartan (TLM), a selective angiotensin II type 1 (AT1 ) receptor blocker, on carbon tetrachloride (CCl4 )-induced acute hepatotoxity in rats. Intraperitoneal injection of male Wistar rats with CCl4 1 mL kg-1 , 1:1 mixture with corn oil for 3 days increas...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22240
更新日期:2017-02-01 00:00:00
abstract::Rheumatoid arthritis (RA) is the most common type of chronic inflammatory disease which is triggered by dysfunction in the immune system which in turn affects synovial joints. Current treatment of RA with NSAIDs and DMRDs is limited by their side effect. As a result, the interest in alternative, well tolerated anti-in...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22264
更新日期:2017-02-01 00:00:00
abstract::Females are born with a finite number of oocyte-containing follicles and ovary damage results in reduced fertility. Cadmium accumulates in the reproductive system, damaging it, and the cigarette smoke is a potential exposure route. Natural therapies are relevant to health benefits and disease prevention. This study ve...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22225
更新日期:2017-01-01 00:00:00
abstract::Methoxychlor (MXC), an organochloride insecticide, is a potent toxicant-targeting female reproductive system and known to cause follicular atresia by inducing apoptosis within granulosa cells. Oxidative stress plays a pivotal role in apoptosis; thus, this study focuses on the ameliorative action of N-acetyl cysteine (...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22221
更新日期:2017-01-01 00:00:00
abstract::Linear alkylbenzene sulfonate (LAS) is an anionic surfactant commonly used in cleaning agents such as laundry detergents. Trace amounts of LAS are released into environmental waters after processing in wastewater treatment plants after the use of this chemical. Acute toxicity of LAS has been well-studied using various...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22217
更新日期:2017-01-01 00:00:00
abstract::Melamine is a heterocyclic, aromatic amine and nitrogen-enriched environmental toxicant, found in not only adulterated foodstuffs but also industrial household tableware and paints. Previous studies demonstrated adverse effects of high-dose melamine on human infants and pregnant animals, but effects of low-dose melami...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22218
更新日期:2017-01-01 00:00:00
abstract::Deguelin, a naturally occurring rotenoid of the flavonoid family, is known to be an Akt inhibitor, to have chemopreventive activities and anti-tumor effect on several cancers. In this study, investigation to elucidate the effect of deguelin on apoptotic pathways in human lung cancer cells and on the anti-tumor effect ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22214
更新日期:2017-01-01 00:00:00
abstract::Acute severe carbon monoxide (CO) poisoning induces hypoxia that leads to cardiovascular and nervous systems disturbances. Different complex mechanisms lead to CO neurotoxicity including lipid peroxidation, inflammatory and immune-mediated reactions, myelin degeneration and finally neuronal apoptosis and necrosis. Gra...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22210
更新日期:2017-01-01 00:00:00
abstract::Bisphenol A (BPA) and cadmium (Cd) are environmental pollutants that are implicated in potential reproductive effects, including damage to the prostate gland. Their action during puberty requires analysis to determine the relationship of these compounds with the testosterone peak that occurs during this phase. This st...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22211
更新日期:2017-01-01 00:00:00
abstract::Fascinating super paramagnetic uniqueness of iron oxide particles at nano-scale level make them extremely useful in the state of the art therapies, equipments, and techniques. Cobalt ferrite (CoFe2 O4 ) magnetic nanoparticles (MNPs) are extensively used in nano-based medicine and electronics, results in extensive disc...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22206
更新日期:2016-12-01 00:00:00
abstract::Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used therapeutic agents; however, their pharmacological actions raise concerns about potential risks to the reproductive health of aquatic vertebrates. In the present study, a medaka ovulation assay was applied as an in vitro model to evaluate NSAID-induced anti...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22173
更新日期:2016-12-01 00:00:00